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Article

Rejuvenation capacity of genetic versus human-optimized chemical reprogramming in cellular aging models

2025-12-01

Abstract excerpt

Cellular reprogramming with transient OSKM expression can reverse aging phenotypes, but genetic factor delivery introduces heterogeneous expression, reprogramming-associated stress, and barriers for therapeutic use. Small-molecule chemical reprogramming is an alternative, yet its performance relative to genetic approaches in human cells is unresolved. We directly compared a human-optimized chemical reprogramming p...

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Literature Corpus work
7f08b537-9d30-52cb-80cb-10fd8da54fdd
DOI
10.1101/2025.11.27.690966
Open publication

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Rejuvenation capacity of genetic versus human-optimized chemical reprogramming in cellular aging modelsDOI 10.1101/2025.11.27.690966
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