Article

Induction of Human Pruriceptors from Pluripotent Stem Cells via Transcription Factors

2025-06-15

Abstract excerpt

<h4>Summary</h4> Pruriception is crucial for defense against external stimuli but can lead to chronic pruritus, a debilitating condition affecting millions worldwide. Our understanding of the cellular and molecular mechanisms behind the sensation of itch has been hindered by the lack of functional human models. Here, we address this limitation by developing a protocol to generate induced pruriceptors (iPruricepto...

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Literature Corpus work: 05310296-be8b-5947-8ff7-665ca29d94dd
DOI: 10.1101/2025.06.11.659208

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