Article

Characterising the function of CDK5RAP2 in the vertebrate centrosome

2010-01-01

Abstract excerpt

The centrosome is the major microtubule organising centre in vertebrate cells. CDK5RAP2 is a human protein that localises to the centrosome. At the start of this thesis work, the function of CDK5RAP2 was uncharacterised. Significantly, cdk5rap2 is one of several centrosomal genes that are mutated in the developmental disorder Primary Microcephaly, where affected individuals have smaller brains than expected for th...

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Literature Corpus work: badfd392-a784-5f0a-b83c-21d18f39d008
DOI: 10.17863/cam.16183

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