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Article

CDK5RAP2 regulates centriole engagement and cohesion in mice.

Developmental cell - 15 Jun 2010

Barrera Jose A, Kao Ling-Rong, Hammer Robert E, Seemann Joachim, Fuchs Jannon L, Megraw Timothy L

Abstract excerpt

Centriole duplication occurs once per cell cycle, ensuring that each cell contains two centrosomes, each containing a mother-daughter pair of tightly engaged centrioles at mitotic entry. Loss of the tight engagement between mother and daughter centrioles appears to license the next round of centriole duplication. However, the molecular mechanisms regulating this process remain largely unknown. Mutations in...

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Identifiers

PMID: 20627074
DOI: 10.1016/j.devcel.2010.05.017
PMCID: PMC3078807

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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