Article

A MOPD II-associated Pericentrin variant disrupts PACT domain dimerization and pericentriolar material recruitment

2026-05-05

Abstract excerpt

Centrosome dysfunction is linked to developmental disorders affecting brain and body size, including microcephaly and primordial dwarfism. However, the cellular mechanisms underlying these rare conditions remain poorly understood. In this study, we investigate a rare variant of the centrosome-associated protein Pericentrin, which was discovered in a single family with Majewski/microcephalic osteodysplastic primord...

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Literature Corpus work: a5e2a1fa-93a2-5f28-bc54-8cb1c3a90c2c
DOI: 10.64898/2026.05.01.722250

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