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Centrosome – a promising anti-cancer target

1 Dec 2016

Abstract excerpt

The centrosome, an organelle discovered >100 years ago, is the main microtubule-organizing center in mammalian organisms. The centrosome is composed of a pair of centrioles surrounded by the pericentriolar material (PMC) and plays a major role in the regulation of cell cycle transitions (G1-S, G2-M, and metaphase-anaphase), ensuring the normality of cell division. Hundreds of proteins found in the centrosome...

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PMID: 28008224
DOI: 10.2147/btt.s87396

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