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Article

Large-scale in silico modeling of metabolic interactions between cell types in the human brain.

Nature biotechnology - 1 Dec 2010

Lewis Nathan E, Schramm Gunnar, Bordbar Aarash, Schellenberger Jan, Andersen Michael P, Cheng Jeffrey K, Patel Nilam, Yee Alex, Lewis Randall A, Eils Roland, König Rainer, Palsson Bernhard Ø

Abstract excerpt

Metabolic interactions between multiple cell types are difficult to model using existing approaches. Here we present a workflow that integrates gene expression data, proteomics data and literature-based manual curation to model human metabolism within and between different types of cells. Transport reactions are used to account for the transfer of metabolites between models of different cell types via the...

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PMID: 21102456
DOI: 10.1038/nbt.1711
PMCID: PMC3140076

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