Article

A convergent metabolic-kinase signaling axis links Parkinson’s disease and multiple system atrophy

2026-06-16

Abstract excerpt

<h4>Summary</h4> Parkinson’s disease (PD) and multiple system atrophy (MSA) are alpha-synucleinopathies with overlapping clinical phenotypes but distinct cellular pathological hallmarks. Whether these disorders share upstream molecular changes beyond alpha-synuclein aggregation remains unresolved. Here, we generated induced pluripotent stem cell (iPSC)-derived midbrain spheroids containing dopaminergic neurons fr...

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Literature Corpus work: f143af9a-a6f6-5f5b-a9c5-555c8deebf3c
DOI: 10.64898/2026.06.11.731777

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