Article

Rational design of respiratory syncytial virus dimeric F-subunit vaccines in protein and mRNA forms

2025-06-01

Abstract excerpt

<h4>SUMMARY</h4> <h4>Background</h4> Respiratory syncytial virus (RSV) poses a significant public health threat, particularly to children and the elderly. Two protein-based vaccines and one mRNA vaccine have been approved, all targeting the prefusion conformation of the fusion (F) glycoprotein. However, it has been reported that the F protein transitions to the post-fusion state during storage, resulting in a re...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bab8a902-bdf9-54dd-b568-81517792122d
DOI: 10.1101/2025.05.31.655981

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Rational design of respiratory syncytial virus dimeric F-subunit vaccines in protein and mRNA formsDOI 10.1101/2025.05.31.655981Read

Robust and Long-Lasting Immunity and Protection in Mice Induced by Lipopolyplex-Delivered mRNA Vaccines Expressing the Prefusion Protein of Respiratory Syncytial VirusSemantic proximity Read

A truncated pre-F protein mRNA vaccine elicits an enhanced immune response and protection against respiratory syncytial virusSemantic proximity Read

Improved mRNA-based RSV vaccine with PreF forming enveloped virus-like particlesSemantic proximity Read

<em>Respiratory Syncytial Virus</em> Vaccine mRNA Lipid Nanoparticles Pattern Determined via BioinformaticsSemantic proximity Read

A foldon-free prefusion F trimer vaccine for respiratory syncytial virus to reduce off-target immune responsesSemantic proximity Read

Generation of novel respiratory syncytial virus vaccine candidate antigens that can induce high levels of prefusion-specific antibodies.Semantic proximity Read

A highly stable prefusion RSV F vaccine derived from structural analysis of the fusion mechanism.Semantic proximity Read

mRNA-LNP Vaccines Encoding for Dengue Optimized prM/ENV Proteins Induce Protective Immunity without ADESemantic proximity Read

Dynamic regulation-based stabilizing mutations are highly effective for designing RSV pre-fusion F mRNA vaccines.Semantic proximity Read

Multiepitope-Based Subunit Vaccine Design and Evaluation against Respiratory Syncytial Virus Using Reverse Vaccinology ApproachSemantic proximity Read

<i>De novo</i> design of a safe and potent respiratory syncytial virus immuno-focusing antigenSemantic proximity Read

A Cysteine Zipper Stabilizes a Pre-Fusion F Glycoprotein Vaccine for Respiratory Syncytial VirusSemantic proximity Read