Article

Robust and Long-Lasting Immunity and Protection in Mice Induced by Lipopolyplex-Delivered mRNA Vaccines Expressing the Prefusion Protein of Respiratory Syncytial Virus

2024-12-27

Abstract excerpt

<h4>Objectives: </h4> Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infections in infants and children. mRNA vaccines based on the lipopolyplex (LPP) platform have been previously reported, but they remain unapplied in RSV vaccine development. In this study, we developed a novel LPP-delivered mRNA vaccine that expresses the respiratory syncytial virus prefusion protein (RSV pre-...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c2d3fe5e-b434-5c67-bf69-7bcc4ee1504d
DOI: 10.20944/preprints202412.2308.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Robust and Long-Lasting Immunity and Protection in Mice Induced by Lipopolyplex-Delivered mRNA Vaccines Expressing the Prefusion Protein of Respiratory Syncytial VirusDOI 10.20944/preprints202412.2308.v1Read

Improved mRNA-based RSV vaccine with PreF forming enveloped virus-like particlesSemantic proximity Read

A truncated pre-F protein mRNA vaccine elicits an enhanced immune response and protection against respiratory syncytial virusSemantic proximity Read

Rational design of respiratory syncytial virus dimeric F-subunit vaccines in protein and mRNA formsSemantic proximity Read

<em>Respiratory Syncytial Virus</em> Vaccine mRNA Lipid Nanoparticles Pattern Determined via BioinformaticsSemantic proximity Read

Design and preclinical assessment of mRNA-1345 prefusion F glycoprotein-encoding mRNA vaccine for respiratory syncytial virusSemantic proximity Read

Design of Lipid Nanoparticles of mRNA Vaccine against Respiratory Syncytial Virus by Bioinformatics in EgyptSemantic proximity Read

Efficacy and safety of an mRNA-based RSV preF vaccine in preclinical studiesSemantic proximity Read

Respiratory syncytial virus vaccine mRNA lipid nanoparticles pattern determined via bioinformaticsSemantic proximity Read

The mRNA vaccine expressing fused structural protein of PRRSV protects piglets against PRRSV challengeSemantic proximity Read

sa-mRNA influenza vaccine raises a higher and more durable immune response than mRNA vaccine in preclinical modelsSemantic proximity Read

The mRNA Vaccine Expressing Single and Fused Structural Proteins of Porcine Reproductive and Respiratory Syndrome Induces Strong Cellular and Humoral Immune Responses in BalB/C MiceSemantic proximity Read

A highly stable prefusion RSV F vaccine derived from structural analysis of the fusion mechanism.Semantic proximity Read