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Dynamic regulation-based stabilizing mutations are highly effective for designing RSV pre-fusion F mRNA vaccines.

Biochemical and biophysical research communications - 6 Aug 2026

Shao Shuai, Dong Ze Yuan, Kang Zi Yao, Zhang Hao, Zheng Xiang, Shen Fu Jie, Jin Yu Qin, Pan Zheng, Li Xin, Liu Ning, Li Xin Ge, Liu Zhao Ming, Zhang Xue Feng, Ren Jin, Han Zi Bo, Liang Yu, Zhang Jing, Su Ji Guo, Li Qi Ming

Abstract excerpt

Respiratory syncytial virus (RSV) is a leading cause of respiratory tract infections and poses a serious threat to young children, older adults, and immunocompromised individuals. We previously designed a pre-fusion stabilized F protein (pre-F), TriM-5, using a dynamic regulation mechanism, and produced a recombinant protein-based vaccine candidate that exhibited potent protection against RSV. However, several...

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PMID: 42172905
DOI: 10.1016/j.bbrc.2026.153958

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