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Deconvolution Of Hematopoietic Stem/Progenitor Cell Signaling Predicts Inflammatory Niche Remodeling To Be A Determinant Of Tissue Failure And Outcome In Human AML

2023-05-07

Abstract excerpt

<h4>ABSTRACT</h4> Cancer initiation is orchestrated by interplay between tumor-initiating cells and their stromal/immune environment. Here, by adapted scRNAsequencing, we decipher the predicted signaling between tissue-resident hematopoietic stem/progenitor cells (HSPCs) and their neoplastic counterparts with their native niches in the human bone marrow. LEPR + stromal cells are identified as central regulators...

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Literature Corpus work: ba950470-ae66-5d09-b88c-2274f6cf757c
DOI: 10.1101/2023.05.05.539525

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