Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integrated OMICs unveil the bone-marrow microenvironment in human leukemia

1 May 2021

Abstract excerpt

The bone-marrow (BM) niche is the spatial environment composed by a network of multiple stromal components regulating adult hematopoiesis. We use multi-omics and computational tools to analyze multiple BM environmental compartments and decipher their mutual interactions in the context of acute myeloid leukemia (AML) xenografts. Under homeostatic conditions, we find a considerable overlap between niche populations...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Hematopoietic Stem Cell Transplantation
Share to Myeloproliferative Neoplasms: Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33979628
DOI: 10.1016/j.celrep.2021.109119

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrated OMICs unveil the bone-marrow microenvironment in human leukemiaPMID 33979628Read ↗

Single-cell characterisation of the hematopoietic bone marrow interactome in health and diseaseSemantic proximity Read ↗

Cell-cell interactome of the hematopoietic niche and its changes in acute myeloid leukemiaSemantic proximity Read ↗

Multi-omics-guided dynamic precision medicine in leukemia: An AML-centered framework integrating genotype, cellular state, bone marrow pathology, and the immune ecosystem.Semantic proximity Read ↗

Multi-omics advances for molecular characterization, precision medicine, and prognostic implications in leukemiaSemantic proximity Read ↗

The Role of the Bone Marrow Microenvironment in the Pathogenesis of Acute Myeloid LeukemiaSemantic proximity Read ↗

The bone marrow microenvironment of pre-B acute lymphoblastic leukemia at single-cell resolutionSemantic proximity Read ↗

Deconvolution Of Hematopoietic Stem/Progenitor Cell Signaling Predicts Inflammatory Niche Remodeling To Be A Determinant Of Tissue Failure And Outcome In Human AMLSemantic proximity Read ↗

A single cell framework for multi-omic analysis of disease identifies malignant regulatory signatures in mixed phenotype acute leukemiaSemantic proximity Read ↗

Spatial Transcriptomics Reveals Inflammation and Trans-differentiation States of Acute Myeloid Leukemia in Extramedullary and Medullary TissuesSemantic proximity Read ↗

Omics approaches: Role in acute myeloid leukemia biomarker discovery and therapySemantic proximity Read ↗

A Proteomics and Transcriptomics Approach to Identify Leukemic Stem Cell (LSC) MarkersSemantic proximity Read ↗

Highly multiplexed proteomic assessment of human bone marrow in acute myeloid leukemiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.