Article

The m6A RNA methylation exerts a neuroprotective function by regulating the expression of α-synuclein

2026-08-06

Abstract excerpt

<title>Abstract</title> <p>Graphical Abstract Mechanisms underlying the regulation of α-Syn expression by m6A RNA modification and its protective effects on dopaminergic neurons Abstract N6-methyladenosine (m6A) is a prevalent and dynamic reversible modification in eukaryotic mRNAs. Recent studies have unveiled the critical role of m6A modification within the nervous system, revealing that its dysregulation is cl...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: dda38f1b-6e50-5994-a364-334d69cf7396
DOI: 10.21203/rs.3.rs-10238426/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The m6A RNA methylation exerts a neuroprotective function by regulating the expression of α-synucleinDOI 10.21203/rs.3.rs-10238426/v1Read

Epitranscriptome Changes in Neurodegenerative Diseases and the Potential Strategy for the TherapeuticsSemantic proximity Read

Dynamics of N6-methyladenosine modification during Alzheimer's disease developmentSemantic proximity Read

m6A Modification in Coding and Non-coding RNAs: Roles and Therapeutic Implications in Cancer.Semantic proximity Read

Reduced levels of N6-methyladenosine in RNA of peripheral blood mononuclear cells from patients with Alzheimer's diseaseSemantic proximity Read

The epitranscriptomic m6A RNA modification modulates synaptic function in ageing and in a mouse model of synucleinopathySemantic proximity Read

m⁶A modification and prion-like domain proteins converge to dysregulate Neuronal RNA Granules in Alzheimer’s diseaseSemantic proximity Read

Genome-Wide m6A Methylation Profiling Reveals Epitranscriptomic Dysregulation in Peripheral Blood Mononuclear Cells from Parkinson's Disease PatientsSemantic proximity Read

Comprehensive analysis across mammalian tissues and cells decipher the underlying mechanism of m6A specificitySemantic proximity Read

The role of m6A and m6Am RNA modifications in the pathogenesis of diabetes mellitusSemantic proximity Read

The regulatory role of m6A modification in the maintenance and differentiation of embryonic stem cellsSemantic proximity Read

Main N6-Methyladenosine Readers: YTH Family Proteins in CancersSemantic proximity Read

Loss of age-associated increase in m <sup>6</sup> A-modified RNA contributes to GABAergic dysregulation in Alzheimer’s diseaseSemantic proximity Read