Back to search

Article

Nuclease-dead S. <i>aureus</i> Cas9 downregulates alpha-synuclein and reduces mtDNA damage and oxidative stress levels in patient-derived stem cell model of Parkinson’s disease

2023-01-24

Abstract excerpt

Parkinson’s disease (PD) is one of the most common neurodegenerative diseases, but no disease modifying therapies have been successful in clinical translation presenting a major unmet medical need. A promising target is alpha-synuclein or its aggregated form, which accumulates in the brain of PD patients as Lewy bodies. While it is not entirely clear which alpha-synuclein protein species is disease relevant, mere...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
b4e9a505-9086-564f-888d-91984544f8b9
DOI
10.1101/2023.01.24.525105
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Nuclease-dead S. <i>aureus</i> Cas9 downregulates alpha-synuclein and reduces mtDNA damage and oxidative stress levels in patient-derived stem cell model of Parkinson’s diseaseDOI 10.1101/2023.01.24.525105
Inactive S. aureus Cas9 downregulates alpha-synuclein and reduces mtDNA damage and oxidative stress levels in human stem cell model of Parkinson’s diseaseSemantic proximity
Robust nuclease-dead S. aureus dCas9-mediated alpha-synuclein knockdown in substantia nigra in a humanized mouse model of Parkinson’s diseaseSemantic proximity
CRISPR-Cas9 Gene Editing Protects from the A53T-SNCA Overexpression-Induced Pathology of Parkinson's Disease In Vivo.Semantic proximity
CRISPR/Cas9-mediated gene editing induces neurological recovery in an A53T-SNCA overexpression rat model of Parkinson’s diseaseSemantic proximity
Randomized CRISPR-Cas Transcriptional Perturbation Screening Reveals Protective Genes against Alpha-Synuclein Toxicity.Semantic proximity
Finding the 'Guilty' Gene Variant of Sporadic Parkinson's Disease Via CRISPR/Cas9.Semantic proximity
<i>SNCA</i> -targeted epigenome therapy for Parkinson’s disease alleviates pathological and behavioral perturbations in a mouse modelSemantic proximity
CRISPR System: A High-throughput Toolbox for Research and Treatment of Parkinson's Disease.Semantic proximity
Alpha-synuclein induces the unfolded protein response in Parkinson’s disease SNCA triplication iPSC-derived neuronsSemantic proximity
Advancements in CRISPR-Based Therapies for Genetic Modulation in Neurodegenerative Disorders.Semantic proximity
Neuronal-type-specific epigenome editing to decrease SNCA expression: Implications for precision medicine in synucleinopathiesSemantic proximity
Global Effects of a PD Risk-SNP at the Alpha-Synuclein LocusSemantic proximity
Select a neighboring publication to make it the new centre.