Article

RNA pull-down-Confocal Nanoscanning (RP-CONA) detects quercetin as pri-miR-7/HuR interaction inhibitor that decreases α-Synuclein levels

2021-01-03

Abstract excerpt

<h4>ABSTRACT</h4> RNA-protein interactions are central to all gene expression processes and contribute to variety of human diseases. Therapeutic approaches targeting RNA-protein interactions have shown promising effects on some diseases that are previously regarded as ‘incurable’. Here we developed a fluorescent on-bead screening platform: RNA pull-down-Confocal Nanoscanning (RP-CONA), to identify RNA-protein int...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3de38f15-721f-525d-a201-60c3ef216402
DOI: 10.1101/2021.01.01.425030

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

RNA pull-down-Confocal Nanoscanning (RP-CONA) detects quercetin as pri-miR-7/HuR interaction inhibitor that decreases α-Synuclein levelsDOI 10.1101/2021.01.01.425030Read

RNA-Targeted Therapies and High-Throughput Screening MethodsSemantic proximity Read

Effective lowering of α-synuclein expression by targeting G-quadruplex structures within the SNCA geneSemantic proximity Read

RNA binding protein AUF1/HNRNPD regulates nuclear export, stability and translation of SNCA transcriptsSemantic proximity Read

Translation of the intrinsically disordered protein α-synuclein is inhibited by a small molecule targeting its structured mRNASemantic proximity Read

Alpha-synuclein abundance and localization are regulated by the RNA-binding protein PUMILIO1Semantic proximity Read

Repurposing niclosamide as a novel anti-SARS-Cov-2 drug by restricting entry protein CD147Semantic proximity Read

Novel regulators of PrP <sup>C</sup> biosynthesis revealed by genome-wide RNA interferenceSemantic proximity Read

A genome-wide RNA interference screening reveals protectiveness of SNX5 knockdown in a Parkinson’s disease cell modelSemantic proximity Read

Repression of α-synuclein expression and toxicity by microRNA-7Semantic proximity Read

Post-transcriptional Regulation of α-Synuclein Expression by mir-7 and mir-153Semantic proximity Read

Depleting prion protein using splice-switching small moleculesSemantic proximity Read

Discovering the 3' UTR-mediated regulation of alpha-synuclein.Semantic proximity Read