Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Translation of the intrinsically disordered protein α-synuclein is inhibited by a small molecule targeting its structured mRNA

3 Jan 2020

Abstract excerpt

Many proteins are refractory to targeting because they lack small-molecule binding pockets. An alternative to drugging these proteins directly is to target the messenger (m)RNA that encodes them, thereby reducing protein levels. We describe such an approach for the difficult-to-target protein α-synuclein encoded by the SNCA gene. Multiplication of the SNCA gene locus causes dominantly inherited Parkinson’s...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Nuclear Receptors and Signaling
Share to Parkinson's Disease Mechanisms and Treatments
Share to RNA regulation and disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31900363
DOI: 10.1073/pnas.1905057117

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Translation of the intrinsically disordered protein α-synuclein is inhibited by a small molecule targeting its structured mRNAPMID 31900363Read ↗

Constitutive translation of human α-synuclein is mediated by the 5′-untranslated regionSemantic proximity Read ↗

The diversity of <i>SNCA</i> transcripts in neurons, and its impact on antisense oligonucleotide therapeuticsSemantic proximity Read ↗

Effective lowering of α-synuclein expression by targeting G-quadruplex structures within the SNCA geneSemantic proximity Read ↗

RNA binding protein AUF1/HNRNPD regulates nuclear export, stability and translation of SNCA transcriptsSemantic proximity Read ↗

Alpha-synuclein abundance and localization are regulated by the RNA-binding protein PUMILIO1Semantic proximity Read ↗

Large-scale bidirectional arrayed genetic screens identify <i>OXR1</i> and <i>EMC4</i> as modifiers of α-synuclein aggregationSemantic proximity Read ↗

Foldamers rescue synucleinopathy phenotypes in multiple in vitro and in vivo models.Semantic proximity Read ↗

Modulating splicing in 5’ untranslated regions to treat rare haploinsufficient diseaseSemantic proximity Read ↗

Nuclease-dead S. <i>aureus</i> Cas9 downregulates alpha-synuclein and reduces mtDNA damage and oxidative stress levels in patient-derived stem cell model of Parkinson’s diseaseSemantic proximity Read ↗

A patient-based model of RNA mis-splicing uncovers treatment targets in Parkinson's disease.Semantic proximity Read ↗

Amido-bridged nucleic acid (AmNA)-modified antisense oligonucleotides targeting α-synuclein as a novel therapy for Parkinson’s diseaseSemantic proximity Read ↗

Randomized CRISPR-Cas Transcriptional Perturbation Screening Reveals Protective Genes against Alpha-Synuclein Toxicity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.