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Article

Silencing of human alpha-synuclein in vitro and in rat brain using lentiviral-mediated RNAi.

Experimental neurology - 1 Apr 2006

Sapru Mohan K, Yates Jonathan W, Hogan Shea, Jiang Lixin, Halter Jeremy, Bohn Martha C

Abstract excerpt

Human alpha-synuclein overexpression and its toxic accumulation in neurons or glia are known to play key roles in the pathogenesis of Parkinson's disease and other related neurodegenerative synucleinopathies. Several single point mutations in the alpha-synuclein gene, as well as gene duplication and triplication, have been linked to familial Parkinson's disease. Moreover, genetic variability of the...

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PMID: 16455076
DOI: 10.1016/j.expneurol.2005.12.024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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