Article

A bioengineered probiotic for the oral delivery of a peptide Kv1.3 channel blocker to treat rheumatoid arthritis

2022-07-13

Abstract excerpt

Engineered microbes for the delivery of biologics is a promising avenue for the treatment of various conditions such as chronic inflammatory disorders and metabolic disease. In this study, we developed a genetically engineered probiotic delivery system that delivers the small molecular biologic to the intestinal tract with high efficacy and minimized side effects. We constructed an inducible system in the probioti...

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Identifiers and source

Literature Corpus work: ba87e33f-2378-5687-963d-6e091ce5e292
DOI: 10.1101/2022.07.12.499749

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A bioengineered probiotic for the oral delivery of a peptide Kv1.3 channel blocker to treat rheumatoid arthritisDOI 10.1101/2022.07.12.499749Read

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