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Article

A small shared epitope-mimetic compound potently accelerates osteoclast-mediated bone damage in autoimmune arthritis.

Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2013

Fu Jiaqi, Ling Song, Liu Ying, Yang Jianyi, Naveh Shirly, Hannah Margaret, Gilon Chaim, Zhang Yang, Holoshitz Joseph

Abstract excerpt

We have recently proposed that the shared epitope (SE) may contribute to rheumatoid arthritis pathogenesis by acting as a ligand that activates proarthritogenic signal transduction events. To examine this hypothesis, in this study we characterized a novel small SE-mimetic compound, c(HS4-4), containing the SE primary sequence motif QKRAA, which was synthesized using a backbone cyclization method. The SE-mimetic...

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Share to Arthritis, Experimental
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23885107
DOI: 10.4049/jimmunol.1203231
PMCID: PMC3753203

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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