Article

Oral delivery of GLP-1R agonist by an engineered probiotic yeast strain has anti-obesity effects in mice

2022-12-21

Abstract excerpt

Obesity is rapidly increasing within the global population and is one of the leading causes of chronic diseases, including type 2 diabetes (T2D), non-alcoholic fatty liver disease, and cardiovascular diseases. Glucagon-like peptide-1 receptor (GLP-1R) agonists have emerged as promising therapeutic agents for treating T2D and obesity. However, the route of administration of the GLP-1R agonists is currently by injec...

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Literature Corpus work: 8a441cd9-ab00-5d78-ada1-93d53edeb3e1
DOI: 10.1101/2022.12.21.521368

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