Article

Oral RNA Interference Therapy for Celiac Disease using a Polymeric Microsphere Formulation

2021-03-10

Abstract excerpt

<title>Abstract</title> <p>Celiac disease is a chronic inflammatory condition characterized by activation of the immune system in response to deamidation of gluten peptides brought about by tissue transglutaminase-2 (TG2). Overexpression of interleukin-15 (IL-15) in the intestinal epithelium and the lamina propria leads to the dysregulation of the immune system, leading to epithelial damage. The goal of this stud...

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Literature Corpus work: 2ace9597-f892-55ab-853d-0f572515c043
DOI: 10.21203/rs.3.rs-311580/v1

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