Article

Oral delivery of semaglutide and tirzepatide using milk-derived small extracellular vesicles

2024-12-29

Abstract excerpt

Therapeutic proteins and peptides have revolutionized modern biomedicine. However, the large size and complex structure of these macromolecules preclude their oral administration, greatly limiting their applications in patient care. Biochemical degradation in the gastrointestinal tract, mucus, and cellular barrier are the major obstacles to oral development. Small extracellular vesicles (sEVs) are natural nano lip...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c1094641-a19c-5637-b5ce-073f148c1d01
DOI: 10.1101/2024.12.28.630566

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Oral delivery of semaglutide and tirzepatide using milk-derived small extracellular vesiclesDOI 10.1101/2024.12.28.630566Read

Milk-Derived Extracellular Vesicles in Inter-Organism, Cross-Species Communication and Drug DeliverySemantic proximity Read

Biological Properties of Milk-Derived Extracellular Vesicles and Their Physiological Functions in InfantSemantic proximity Read

Nanoliposome technology for the food and nutraceutical industriesSemantic proximity Read

Bacterial extracellular vesicles as a tunable platform for vaginal drug deliverySemantic proximity Read

Advancements in Drug Delivery Systems from Chewable Tablets to NanomedicineSemantic proximity Read

Milk‐Derived Small Extracellular Vesicles Promote Recovery of Intestinal Damage by Accelerating Intestinal Stem Cell‐Mediated Epithelial RegenerationSemantic proximity Read

Unified Approaches in Modern Drug Delivery Covering Lipid Based Nanocarriers Controlled Release Mechanisms and Innovative Tablet TechnologiesSemantic proximity Read

Oral Spatiotemporal Nanoassembly for Sequential Genetic Reprogramming from Gut to Periphery OrganSemantic proximity Read

Next-Generation Liposomal Drug Delivery Systems: Core Principles, Innovations, and Targeting StrategiesSemantic proximity Read

Harnessing extracellular vesicles for efficient siRNA delivery <i>in vitro</i> and <i>in vivo</i>Semantic proximity Read

Dynamic Covalent Disulfide Exchange Mediates Oral Delivery of BiomacromoleculesSemantic proximity Read

Emerging Horizons in Lipid Based Drug Delivery Systems and Nanocarrier TherapeuticsSemantic proximity Read