Article

An orally administered peptide hydrogel disentangles immune-microbiota crosstalk for long-term ulcerative colitis therapy

2026-08-24

Abstract excerpt

Ulcerative colitis (UC) is a global health challenge driven by immune dysregulation and gut microbiota imbalance.1 Current treatments, limited by insufficient efficacy and systemic toxicity during prolonged use, fail to resolve the intertwined immune-microbial pathology.2 Here, we report an orally administered self-assembled hydrogel C₁₂-(IIRR)₂I-NH₂ (CIR), engineered from host defense peptides, which disrupts the...

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Literature Corpus work: d92ed4ff-1b8f-5759-98c2-ee2c49240fa5
DOI: 10.64898/2026.08.22.746417

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