Article

Regulating IL-2 immune signaling function via a core allosteric structural network

2024-10-08

Abstract excerpt

Human interleukin-2 (IL-2) is a crucial cytokine for T cell regulation, with therapeutic potential in cancer and autoimmune diseases. However, IL-2’s pleiotropic effects across different immune cell types often lead to toxicity and limited efficacy. Previous efforts to enhance IL-2’s therapeutic profile have focused on modifying its receptor binding sites. Yet, the underlying dynamics and intramolecular networks c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ba5c8d2d-d7f7-50e2-881a-1d4de6e619cc
DOI: 10.1101/2024.10.07.617024

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Regulating IL-2 immune signaling function via a core allosteric structural networkDOI 10.1101/2024.10.07.617024Read

Interleukin-2 activity can be fine tuned with engineered receptor signaling clamps.Semantic proximity Read

Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'.Semantic proximity Read

Site-Mutation of Hydrophobic Core Residues Synchronically Poise Super Interleukin 2 for Signaling: Identifying Distant Structural Effects through Affordable Computations.Semantic proximity Read

Insights into the binding recognition and computational design of IL-2 muteins with enhanced predicted binding affinity to the IL-2 receptor α.Semantic proximity Read

AI-Driven Design of Nanobinders Targeting the TSLPR Heterodimer Interface to Suppress Type 2 Inflammatory SignalingSemantic proximity Read

Directed disruption of IL2 aggregation sites produces designer biologics with enhanced specificity coupled to improved production capacitySemantic proximity Read

Regulatory T cell expansion by a highly CD25-dependent IL-2 mutein arrests ongoing autoimmunitySemantic proximity Read

Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations.Semantic proximity Read

Cryo‐EM structure of the IL‐10 receptor complex provides a blueprint for ligand engineeringSemantic proximity Read

Redirecting cell-type specific cytokine responses with engineered interleukin-4 superkines.Semantic proximity Read

Tuning Insulin Receptor Signaling Using <i>De Novo</i> Designed AgonistsSemantic proximity Read

The antitumor effect induced by an IL-2 'no-alpha' mutein depends on changes in the CD8+ T lymphocyte/Treg cell balance.Semantic proximity Read