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Article

Regulating IL-2 Immune Signaling Function Via A Core Allosteric Structural Network.

Journal of molecular biology - 15 Jan 2025

Woodward Claire H, Solieva Shahlo O, Hwang Daniel, De Paula Viviane S, Fabilane Charina S, Young Michael C, Trent Tony, Teeley Ella C, Majumdar Ananya, Spangler Jamie B, Bowman Gregory R, Sgourakis Nikolaos G

Abstract excerpt

Human interleukin-2 (IL-2) is a crucial cytokine for T cell regulation, with therapeutic potential in cancer and autoimmune diseases. However, IL-2's pleiotropic effects across different immune cell types often lead to toxicity and limited efficacy. Previous efforts to enhance IL-2's therapeutic profile have focused on modifying its receptor binding sites. Yet, the underlying dynamics and intramolecular networks...

Read the complete abstract on PubMed

Topics

Interleukin-2
Humans
Molecular Dynamics Simulation
Signal Transduction
Allosteric Regulation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Protein Conformation

Mutation

Protein Binding

T-Lymphocytes

Receptors, Interleukin-2

Binding Sites

Source

Open in PubMed Open full text

Identifiers

PMID: 39662679
DOI: 10.1016/j.jmb.2024.168892
PMCID: PMC12077578

Provenance

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