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Article

Redirecting cell-type specific cytokine responses with engineered interleukin-4 superkines.

Nature chemical biology - 1 Dec 2012

Junttila Ilkka S, Creusot Remi J, Moraga Ignacio, Bates Darren L, Wong Michael T, Alonso Michael N, Suhoski Megan M, Lupardus Patrick, Meier-Schellersheim Martin, Engleman Edgar G, Utz Paul J, Fathman C Garrison, Paul William E, Garcia K Christopher

Abstract excerpt

Cytokines dimerize their receptors, with the binding of the 'second chain' triggering signaling. In the interleukin (IL)-4 and IL-13 system, different cell types express varying numbers of alternative second receptor chains (γc or IL-13Rα1), forming functionally distinct type I or type II complexes. We manipulated the affinity and specificity of second chain recruitment by human IL-4. A type I receptor-selective...

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Identifiers

PMID: 23103943
DOI: 10.1038/nchembio.1096
PMCID: PMC3508151

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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