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Transient DNA methyltransferase 3a (DNMT3a) Inhibition Unlocks dedifferentiation and Neurogenic Potential in Mouse Retinal Müller Glia

2025-07-26

Abstract excerpt

The regenerative response of retinal cells to injury and aging depends on the epigenomic plasticity that enables the dedifferentiation and neuronal differentiation capacities of Müller glial cells (MG). In mammals, this regenerative ability is extremely limited, and disruptions in epigenetic mechanisms, particularly those involving DNA methylation and demethylation, may underlie this restricted potential. To explo...

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Literature Corpus work
ba4778e2-4f50-553d-a197-ee9d862a5a77
DOI
10.1101/2025.07.25.666728
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Transient DNA methyltransferase 3a (DNMT3a) Inhibition Unlocks dedifferentiation and Neurogenic Potential in Mouse Retinal Müller GliaDOI 10.1101/2025.07.25.666728
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