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Restoration of retinal regenerative potential of Müller glia by disrupting intercellular Prox1 transfer

25 Mar 2025

Abstract excerpt

Individuals with retinal degenerative diseases struggle to restore vision due to the inability to regenerate retinal cells. Unlike cold-blooded vertebrates, mammals lack Müller glia (MG)-mediated retinal regeneration, indicating the limited regenerative capacity of mammalian MG. Here, we identify prospero-related homeobox 1 (Prox1) as a key factor restricting this process. Prox1 accumulates in MG of degenerating...

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PMID: 40133314
DOI: 10.1038/s41467-025-58290-8

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