Article

Suppressing DNMT3a Alleviates the Intrinsic Epigenetic Barrier for Optic Nerve Regeneration and Restores Vision in Adult Mice

2023-11-18

Abstract excerpt

<h4>ABSTRACT</h4> The limited regenerative potential of the optic nerve in adult mammals presents a major challenge for restoring vision after optic nerve trauma or disease. The mechanisms of this regenerative failure are not fully understood 1,2 . Here, through small-molecule and genetic screening for epigenetic modulators 3 , we identify DNA methyltransferase 3a (DNMT3a) as a potent inhibitor of axon regenera...

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Literature Corpus work: 4c7c9fd8-a9bf-5717-893d-4e0b589248c7
DOI: 10.1101/2023.11.17.567614

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