Article

Stimulating the regenerative capacity of the human retina with proneural transcription factors in 3D cultures

2024-09-24

Abstract excerpt

Retinal diseases often lead to degeneration of specific retinal cell types with currently limited therapeutic options to replace the lost neurons. Previous studies have reported that overexpression of ASCL1 or combinations of proneural factors in Müller glia (MG) induces regeneration of functional neurons in the adult mouse retina. Recently, we applied the same strategy in dissociated cultures of fetal human MG an...

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Literature Corpus work: c39d4326-924c-5f1d-9591-0f8537f11b71
DOI: 10.1101/2024.09.24.614778

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