Back to search

Article

Dynamic expression of ASCL1 drives neurogenesis from infant and adult macaque Müller glia into immature retinal ganglion cells

2025-08-25

Abstract excerpt

Strategies to stimulate the regeneration of neurons in the adult central nervous system can offer universal solutions for neurodegenerative diseases. Taking lessons from naturally regenerating species, such as the zebrafish, we have previously shown that vector-mediated expression of proneural transcription factors can stimulate neurogenesis from the resident Müller glia (MG) population in the adult mouse retina,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
296848b4-b854-59af-8e0b-55298ce3a44b
DOI
10.1101/2025.08.21.671552
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Dynamic expression of ASCL1 drives neurogenesis from infant and adult macaque Müller glia into immature retinal ganglion cellsDOI 10.1101/2025.08.21.671552
Stimulating the regenerative capacity of the human retina with proneural transcription factors in 3D culturesSemantic proximity
Efficient stimulation of retinal regeneration from Müller glia in adult mice using combinations of proneural bHLH transcription factors.Semantic proximity
AAV-mediated expression of proneural factors stimulates neurogenesis from adult Müller glia <i>in vivo</i> .Semantic proximity
AAV-mediated generation of neurons in injury-induced and inherited retinal degenerationsSemantic proximity
STAT pathway activation limits the Ascl1-mediated chromatin remodeling required for neural regeneration from Müller glia in adult mouse retinaSemantic proximity
Cis-Regulatory Accessibility Directs Muller Glial Development and Regenerative CapacitySemantic proximity
Evidence of Müller glia conversion into retina ganglion cells using Neurogenin2Semantic proximity
Transient DNA methyltransferase 3a (DNMT3a) Inhibition Unlocks dedifferentiation and Neurogenic Potential in Mouse Retinal Müller GliaSemantic proximity
Single cell RNA sequencing unravels the transcriptional network underlying zebrafish retina regenerationSemantic proximity
Molecular regulation of retinal regeneration is context specificSemantic proximity
Stimulating neurogenesis of distinct retinal lineages in human retinal pigmented epithelium (RPE) with proneural transcription factorsSemantic proximity
Directed robust generation of functional retinal ganglion cells from Müller gliaSemantic proximity
Select a neighboring publication to make it the new centre.