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Heparan Sulfate Proteoglycans Mediate In Vitro Human Neuronal Lineage Specification

2025-06-25

Abstract excerpt

Heparan sulfate proteoglycans (HSPGs) within the neuronal niche are expressed during brain development, con-tributing to multiple aspects of neurogenesis, yet their roles in glial lineage commitment remain elusive. This study utilised three human cell models expanded under basal culture conditions followed by media induced lineage in-duction to identify a reproducible and robust model of gliogenesis. SH-SY5Y human...

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Literature Corpus work
ba302fcc-8064-5e20-a330-67db3e10dc86
DOI
10.20944/preprints202506.2045.v1
Open publication

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Heparan Sulfate Proteoglycans Mediate In Vitro Human Neuronal Lineage SpecificationDOI 10.20944/preprints202506.2045.v1
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