Article

COMBO-RATE: An experimentally validated bioinformatic tool to identify promiscuous HLA restrictions

2026-04-17

Abstract excerpt

<h4>SUMMARY</h4> Defining HLA restriction of T cell epitopes is essential for understanding immune responses in infectious disease, autoimmunity, and vaccine design. Current bioinformatic programs, including the IEDB RATE tool, enable inference of single-HLA restrictions from immune response data of HLA-typed donors. However, T cell epitopes are frequently presented by multiple HLA alleles, a phenomenon termed pr...

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Literature Corpus work: ba03ae9b-8fc0-5124-9e9a-a0738508925f
DOI: 10.64898/2026.04.14.718521

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