Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PopCover-2.0. Improved Selection of Peptide Sets With Optimal HLA and Pathogen Diversity Coverage.

Frontiers in immunology - 1 Jan 2021

Nilsson Jonas Birkelund, Grifoni Alba, Tarke Alison, Sette Alessandro, Nielsen Morten

Abstract excerpt

The use of minimal peptide sets offers an appealing alternative for design of vaccines and T cell diagnostics compared to conventional whole protein approaches. T cell immunogenicity towards peptides is contingent on binding to human leukocyte antigen (HLA) molecules of the given individual. HLA is highly polymorphic, and each variant typically presents a different repertoire of peptides. This polymorphism...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD4-Positive T-Lymphocytes
Share to CD8-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to COVID-19

Share to Epitopes, T-Lymphocyte

Share to HLA Antigens

Share to Immunogenicity, Vaccine

Share to Immunologic Techniques

Share to SARS-CoV-2

Source

Open in PubMed Open full text

Identifiers

PMID: 34484239
DOI: 10.3389/fimmu.2021.728936
PMCID: PMC8416060

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PopCover-2.0. Improved Selection of Peptide Sets With Optimal HLA and Pathogen Diversity Coverage.PMID 34484239Read ↗

PEPVAC: a web server for multi-epitope vaccine development based on the prediction of supertypic MHC ligandsSemantic proximity Read ↗

Effective assessment of CD4 <sup>+</sup> T cell Immunodominance patterns: impact of antigen processing and HLA restrictionSemantic proximity Read ↗

Prioritization of SARS-CoV-2 epitopes using a pan-HLA and global population inference approachSemantic proximity Read ↗

A high-throughput immunopeptidome platform for MHC II alleles to characterize antigen-specific CD4 <sup>+</sup> T cellsSemantic proximity Read ↗

PREDIVAC: CD4+ T-cell epitope prediction for vaccine design that covers 95% of HLA class II DR protein diversity.Semantic proximity Read ↗

A Proteome-Wide Immunoinformatics Tool to Accelerate T-Cell Epitope Discovery and Vaccine Design in the Context of Emerging Infectious Diseases: An Ethnicity-Oriented ApproachSemantic proximity Read ↗

OptiTope--a web server for the selection of an optimal set of peptides for epitope-based vaccines.Semantic proximity Read ↗

A Globally Representative Immunopeptidomics Approach to Identify Population-Wide Vaccine CandidatesSemantic proximity Read ↗

Robust computational design and evaluation of peptide vaccines for cellular immunity with application to SARS-CoV-2Semantic proximity Read ↗

High-resolution profiling of MHC II peptide presentation capacity reveals SARS-CoV-2 CD4 T cell targets and mechanisms of immune escapeSemantic proximity Read ↗

Evaluation of peptide selection approaches for epitope-based vaccine design.Semantic proximity Read ↗

COMBO-RATE: An experimentally validated bioinformatic tool to identify promiscuous HLA restrictionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.