Article

Depletion of IgG-producing plasma cells in the colon by treatment of proteasome inhibitor ameliorates chronic DSS-induced colitis in mice

2025-10-28

Abstract excerpt

<title>Abstract</title> <p>Basal plasmacytosis is a histopathological hallmark of ulcerative colitis (UC). However, the precise roles of plasma cells in UC pathogenesis remains unknown. In this study, we investigated the effects of a proteasome inhibitor, which depletes plasma cells, on chronic colitis progression in mice to clarify their contribution to disease pathogenesis. Chronic colitis was induced in female...

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Literature Corpus work: ba021fc2-1ae6-565e-9aa1-c77b0a086a68
DOI: 10.21203/rs.3.rs-7646295/v1

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