Article

Gut-associated lymphoid tissue attrition associates with response to anti-α4β7 therapy in ulcerative colitis

2023-01-20

Abstract excerpt

Targeting the α4β7-MAdCAM-1 axis with vedolizumab (VDZ) is a front-line therapeutic paradigm in ulcerative colitis (UC). However, mechanism(s) of action (MOA) of VDZ remain relatively undefined. Here, we examined three distinct cohorts of patients with UC (n=83, n=60, and n=21), to determine the effect of VDZ on the mucosal and peripheral immune system. Transcriptomic studies with protein level validation were use...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 73b98867-b236-5cbe-94c5-1c903f7d08b7
DOI: 10.1101/2023.01.19.524731

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Gut-associated lymphoid tissue attrition associates with response to anti-α4β7 therapy in ulcerative colitisDOI 10.1101/2023.01.19.524731Read

Single-cell and spatial multi-omics highlight effects of anti-integrin therapy across cellular compartments in ulcerative colitisSemantic proximity Read

Vedolizumab is associated with changes in innate rather than adaptive immunity in patients with inflammatory bowel disease.Semantic proximity Read

Multimodal Profiling of Peripheral Blood Identifies Proliferating Circulating Effector CD4+ T Cells as Predictors for Response to Integrin α4β7-Blocking Therapy in Inflammatory Bowel Disease.Semantic proximity Read

High-dimensional single-cell analysis identifies cellular signatures associated with response to vedolizumab therapy in ulcerative colitisSemantic proximity Read

DNAM-1 immunoreceptor integrates innate and adaptive immune programs to drive intestinal inflammationSemantic proximity Read

A Gut-Specific Bispecific Combining MAdCAM-1 Blockade and IL-22 Signaling to Halt T-Cell Inflammation and Promote Mucosal RestorationSemantic proximity Read

Multi-centered T cell repertoire profiling identifies novel alterations in the immune repertoire of individuals with inflammatory bowel disease and validates previous findingsSemantic proximity Read

Identification of Candidate Biomarkers Associated with Response to Vedolizumab in Inflammatory Bowel Disease.Semantic proximity Read

A dynamic atlas of immunocyte migration from the gutSemantic proximity Read

Simultaneous Profiling of the Blood and Gut T and B Cell Repertoires in Crohn’s Disease and Symptomatic Controls Illustrates Tissue-specific Alterations in the Immune Repertoire of Crohn’s Disease PatientsSemantic proximity Read

Remodeling of human colon plasma cell repertoire in ulcerative colitisSemantic proximity Read

UC-associated autoantibodies to αvβ6 inhibit mucosal TGFβ activation and predispose to intestinal inflammationSemantic proximity Read