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Cyclosporine A alleviates colitis by inhibiting the formation of neutrophil extracellular traps via regulating the pentose phosphate pathway

2023-02-14

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> The aberrant formation of neutrophil extracellular traps (NETs) has been implicated in ulcerative colitis (UC), a chronic recurrent intestinal inflammation. Cyclosporine A (CsA) is now applied as rescue therapy for acute severe UC. In addition, it has been curtained that CsA inhibits the formation of NETs in <italic>vitro</italic> and the mechanism of which was...

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Literature Corpus work
954bba61-e7d5-5fa5-bff0-65ccccbce0a9
DOI
10.21203/rs.3.rs-2556789/v1
Open publication

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