Article

GZMA Suppressed GPX4-mediated Ferroptosis to Improve Intestinal Mucosal Barrier Function in Inflammatory Bowel Disease

2024-04-09

Abstract excerpt

<title>Abstract</title> Background Intestinal epithelial cells (IECs) is a critical component in maintaining intestinal homeostasis. Our previous study demonstrated a decreased population of colonic CD8+CD39+ T cells in pediatric-onset colitis and inflammatory bowel disease (IBD), and further revealed an enrichment of granzyme A (GZMA) in CD8+CD39+ T cells. However,...

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Literature Corpus work: 6fb751ff-ef20-5cea-90b6-f212dcaf5735
DOI: 10.21203/rs.3.rs-4157505/v1

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