Article

Demographic history impacts stratification in polygenic scores

2020-07-20

Abstract excerpt

Large genome-wide association studies (GWAS) have identified many loci exhibiting small but statistically significant associations with complex traits and disease risk. However, control of population stratification continues to be a limiting factor, particularly when calculating polygenic scores where subtle biases can cumulatively lead to large errors. We simulated GWAS under realistic models of demographic histo...

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Literature Corpus work: 74799563-501e-55e7-b23e-2cb62f87cd49
DOI: 10.1101/2020.07.20.212530

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