Article

Hepatic LRP-1 plays an important role in amyloidosis in Alzheimer’s disease mice: Potential role in chronic heavy alcohol feeding

2024-03-19

Abstract excerpt

<title>Abstract</title> <bold>Background: </bold>Hepatic<bold> </bold>lipoprotein receptor-related protein 1 (LRP-1) plays a central role in peripheral Aβ clearance, but its importance in Alzheimer’s disease (AD) pathology is understudied. Our previous work showed that intragastric alcohol feeding to C57BL/6Jmice reduced hepatic LRP-1 expression which correlated with significant AD-relevant changes in the brai...

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Literature Corpus work: b9cde664-92b9-508e-aa80-0271236fe2dc
DOI: 10.21203/rs.3.rs-4110239/v1

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