Article

Different hotspot p53 mutants exert distinct phenotypes and predict outcome of colorectal cancer patients

2021-06-04

Abstract excerpt

<title>Abstract</title> <p>Colorectal cancer (CRC) is the third most common cancer worldwide. The <italic>TP53</italic> gene is mutated in approximately 60% of all CRC cases. Sporadic CRC is characterized by high prevalence of <italic>TP53</italic> hotspot missense mutations. In particular, over 20 percent of all <italic>TP53</italic>-mutated CRC tumors carry either the p53<sup>R175H</sup> structural mutant or th...

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Literature Corpus work: b9c9530e-c64b-5248-b169-b09257eb01ea
DOI: 10.21203/rs.3.rs-523301/v1

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