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Mutant p53 in colon cancer

27 Nov 2018

Abstract excerpt

The accumulation of genetic alterations in driver genes is responsible for the development and malignant progression of colorectal cancer. Comprehensive genome analyses have revealed the driver genes, including APC, KRAS, TGFBR2, and TP53, whose mutations are frequently found in human colorectal cancers. Among them, the p53 mutation is found in ~60% of colorectal cancers, and a majority of mutations are...

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PMID: 30496442
DOI: 10.1093/jmcb/mjy075

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