Article
Different hotspot p53 mutants exert distinct phenotypes and predict outcome of colorectal cancer patients.
Nature communications - 19 May 2022
Hassin Ori, Nataraj Nishanth Belugali, Shreberk-Shaked Michal, Aylon Yael, Yaeger Rona, Fontemaggi Giulia, Mukherjee Saptaparna, Maddalena Martino, Avioz Adi, Iancu Ortal, Mallel Giuseppe, Gershoni Anat, Grosheva Inna, Feldmesser Ester, Ben-Dor Shifra, Golani Ofra, Hendel Ayal, Blandino Giovanni, Kelsen David, Yarden Yosef, Oren Moshe
Abstract excerpt
The TP53 gene is mutated in approximately 60% of all colorectal cancer (CRC) cases. Over 20% of all TP53-mutated CRC tumors carry missense mutations at position R175 or R273. Here we report that CRC tumors harboring R273 mutations are more prone to progress to metastatic disease, with decreased survival, than those with R175 mutations. We identify a distinct transcriptional signature orchestrated by p53R273H,...
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