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P53-R273H mutation enhances colorectal cancer stemness through regulating specific lncRNAs

28 Aug 2019

Abstract excerpt

BACKGROUND: TP53 is one of the most frequently mutated genes among all cancer types, and TP53 mutants occur more than 60% in colorectal cancer (CRC). Among all mutants, there are three hot spots, including p53-R175H, p53-R248W and p53-R273H. Emerging evidence attributes cancer carcinogenesis to cancer stem cells (CSCs). Long noncoding RNAs (lncRNAs) play crucial roles in maintaining the stemness of CSCs. However,...

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PMID: 31455383
DOI: 10.1186/s13046-019-1375-9

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