Back to search

Article

Metastatic Burden and TP53 Mutation Overshadow the Independent Prognostic Value of KRAS in Colorectal Cancer

2025-12-17

Abstract excerpt

<title>Abstract</title> <p> Background The independent prognostic value of <italic>KRAS</italic> mutation in colorectal cancer (CRC) remains controversial, often yielding inconsistent results across studies. We hypothesized that its impact might be overestimated when confounding clinical factors, such as metastatic burden, are rigorously controlled. Methods In this single-center retrospective study, we enrol...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
82b650be-493c-580b-ab7e-640a8d75a845
DOI
10.21203/rs.3.rs-8327424/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Metastatic Burden and TP53 Mutation Overshadow the Independent Prognostic Value of KRAS in Colorectal CancerDOI 10.21203/rs.3.rs-8327424/v1
KRAS Mutation Status as a Prognostic Marker and Predictor of Therapy Response in Colorectal Cancer: an NCDB Analysis.Semantic proximity
Prognostic implications of tumor mutation burden in postoperative patients with colorectal cancer who received capecitabine-based adjuvant chemotherapy: a retrospective exploratory studySemantic proximity
Combined KRAS and TP53 mutation in patients with colorectal cancer enhance chemoresistance to promote postoperative recurrence and metastasis.Semantic proximity
Prognostic value of KRAS mutation in patients undergoing pulmonary metastasectomy for colorectal cancer: A systematic review and meta-analysis.Semantic proximity
Next-Generation Sequencing-Based Analysis of the Genetic Mutation Spectrum in Colorectal Cancer: A Large Single‑Center Study From Southeast China With Cross‑Population Comparison.Semantic proximity
The Prognostic Impact of KRAS G12C Mutation in Patients with Metastatic Colorectal Cancer: A Multicenter Retrospective Observational Study.Semantic proximity
The heterogeneous impact of targeted therapy on the prognosis of stage III/IV colorectal cancer patients with different subtypes of TP53 mutations.Semantic proximity
Association of Kras mutation with tumor deposit status and overall survival of colorectal cancerSemantic proximity
KRAS, APC, and TP53 mutations define opposing immune archetypes in stage III colorectal cancerSemantic proximity
The prognostic role of p53 mutations in metastatic colorectal cancer: A systematic review and meta-analysis.Semantic proximity
KRAS and BRAF Mutations as survival prognostic factors for Metastatic Colorectal Cancer patients after Lung metastasectomy: A Systematic Review and Meta-AnalysisSemantic proximity
Mutation Status of RAS, TP53 , and SMAD4 is Superior to Mutation Status of RAS Alone for Predicting Prognosis after Resection of Colorectal Liver MetastasesSemantic proximity
Select a neighboring publication to make it the new centre.