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Article

Tumor suppressor APC is an attenuator of spindle-pulling forces during C. elegans asymmetric cell division.

Proceedings of the National Academy of Sciences of the United States of America - 30 Jan 2018

Sugioka Kenji, Fielmich Lars-Eric, Mizumoto Kota, Bowerman Bruce, van den Heuvel Sander, Kimura Akatsuki, Sawa Hitoshi

Abstract excerpt

The adenomatous polyposis coli (APC) tumor suppressor has dual functions in Wnt/β-catenin signaling and accurate chromosome segregation and is frequently mutated in colorectal cancers. Although APC contributes to proper cell division, the underlying mechanisms remain poorly understood. Here we show that Caenorhabditis elegans APR-1/APC is an attenuator of the pulling forces acting on the mitotic spindle. During...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29348204
DOI: 10.1073/pnas.1712052115
PMCID: PMC5798331

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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