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Article

The tumor suppressor Apc controls planar cell polarities central to gut homeostasis.

The Journal of cell biology - 6 Aug 2012

Bellis Julien, Duluc Isabelle, Romagnolo Béatrice, Perret Christine, Faux Maree C, Dujardin Denis, Formstone Caroline, Lightowler Sally, Ramsay Robert G, Freund Jean-Noël, De Mey Jan R

Abstract excerpt

The stem cells (SCs) at the bottom of intestinal crypts tightly contact niche-supporting cells and fuel the extraordinary tissue renewal of intestinal epithelia. Their fate is regulated stochastically by populational asymmetry, yet whether asymmetrical fate as a mode of SC division is relevant and whether the SC niche contains committed progenitors of the specialized cell types are under debate. We demonstrate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22851318
DOI: 10.1083/jcb.201204086
PMCID: PMC3413367

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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