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Antibody-mediated targeting of the transferrin receptor in cancer cells

1 Nov 2016

Abstract excerpt

Iron is essential for cell growth and is imported into cells in part through the action of transferrin (Tf), a protein that binds its receptor (TfR1 or CD71) on the surface of a cell, and then releases iron into endosomes. TfR1 is a single pass type-II transmembrane protein expressed at basal levels in most tissues. High expression of TfR1 is typically associated with rapidly proliferating cells, including...

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PMID: 29421281
DOI: 10.1016/j.bmhimx.2016.11.004

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