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Article

Preclinical transfusion-dependent humanized mouse model of beta thalassemia major.

Blood - 7 May 2009

Huo Yongliang, McConnell Sean C, Ryan Thomas M

Abstract excerpt

A preclinical humanized mouse model of beta thalassemia major or Cooley anemia (CA) was generated by targeted gene replacement of the mouse adult globin genes in embryonic stem cells. The mouse adult alpha and beta globin genes were replaced with adult human alpha globin genes (alpha2alpha1) and a human fetal to adult hemoglobin (Hb)-switching cassette (gamma(HPFH)deltabeta(0)), respectively. Similar to human...

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Identifiers

PMID: 19258591
DOI: 10.1182/blood-2008-12-197012
PMCID: PMC2680376

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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